Disopan 1mg (50pcs Box)

Indications of Disopan 1 Tablet

A prescription drug called Disopan 1 is used to treat panic and anxiety disorders, as well as epilepsy (seizures). It helps to calm the brain and lessen abnormal and excessive nerve cell activity.

Pharmacology of Disopan 1 Tablet

Clonazepam has pharmacological properties similar to those of benzodiazepines, including anticonvulsant, sedative, muscle relaxing, and anxiolytic effects. An increase in GABAergic neurotransmission at inhibitory synapses mediates the effects of benzodiazepines on the central nervous system. The presence of benzodiazepines increases the positive allosteric modulation of the GABA receptor for the neurotransmitter, which causes released GABA to have a greater impact on the postsynaptic transmembrane chloride ion flow.

There is more proof that clonazepam affects serotonin in animals. According to animal studies and electroencephalographic studies in humans, clonazepam suppresses a wide variety of paroxysmal activity, including spike and wave discharge in the absence of seizures (petit mal), slow spike-wave, generalized spike-wave, spikes with temporal or other locations, as well as irregular spikes and waves. More frequently than abnormalities in particular areas, general EEG abnormalities are repressed. These studies suggest that clonazepam may be useful in both generalized and localized epilepsies.

Dosage & Administration of Disopan 1 Tablet

Oral:

Adults: 

• For adults with seizure disorders, the first dose shouldn't be more than 1.5 mg/day divided into three doses. The dosage can be raised by 0.5 to 1 mg every three days until seizures are adequately under control or until side effects make a dosage increase impossible. Each patient's maintenance dosage needs to be tailored to their response. The maximum dose that is suggested each day is 20 mg.
• Adults with panic disorder should start with a 0.25 mg dose, divided into two doses. After three days, the 1 mg/day target dose for the majority of patients may be raised.

Pediatric Patients: 

The initial dose for infants and children (up to 30 kg of body weight or 10 years of age) should be between 0.01 and 0.03 mg/kg/day but not more than 0.05 mg/kg/day given in two or three divided doses to reduce drowsiness.

Interaction of Disopan 1 Tablet

Phenytoin, carbamazepine, and phenobarbital pharmacokinetics do not appear to be affected by clonazepam. Clonazepam's impact on the metabolism of other medications has not been studied.

Contraindications

It should not be used in individuals who have a history of benzodiazepine hypersensitivity, as well as those who have clinical or biochemical indications of severe liver damage. It can be utilized in individuals with open-angle glaucoma who are on the right medication, but it's not recommended for acute narrow-angle glaucoma.

Side Effects of Disopan 1 Tablet

The most typical side effects of clonazepam include central nervous system depression (CNS). Around 50% of patients with seizures have experienced drowsiness, and 30% have ataxia, according to reports. In some circumstances, these might get better with time; about 25% of people have reported having behavior problems. Some of the symptoms that may appear include aphonia, coma, tremors, vertigo, disorientation, sadness, forgetfulness, hallucinations, hysteria, increased libido, insomnia, psychosis, and palpitations.

Pregnancy & Lactation

Pregnancy:

It cannot be ruled out from preclinical studies that clonazepam has the possibility of birth defects. From epidemiological evaluation, there is evidence that anticonvulsants can be used as teratogens. However, it is difficult to determine from published epidemiological reports which drug or drug combination is the cause of neonatal defects. There is also the possibility that other factors exist. For example, genetic factors or epilepsy itself may be more important than medications in causing birth defects. In these cases, the drug should be used for pregnant women only when the potential benefits outweigh the risks to the fetus. During pregnancy, clonazepam should only be used if there are compelling indications. The use of high doses in the last trimester of pregnancy or during delivery can cause irregular heartbeats in the fetus and neonatal hypothermia, hypotonia, mild respiratory depression, and poor diet. It should be remembered that both pregnancy itself and sudden withdrawal from the drug can cause seizures. Benzodiazepines occasionally cause withdrawal symptoms in newborns.

Nursing Mothers:

Although only a small amount of the active ingredient in clonazepam has been found to pass into breast milk, mothers receiving this drug should not breastfeed. If there are convincing indications for clonazepam, breastfeeding should be stopped.

Precautions & Warnings

Clonazepam may increase the incidence or hasten the start of generalized tonic-clonic seizures in individuals who have multiple distinct forms of seizure disorders. This may necessitate the addition of or an increase in the dosage of anticonvulsants. The use of valproic acid and Clonazepam at the same time might cause absent status.

Storage Conditions

Keep away from light and heat in a dry area. Keep out of children's reach